Phase 1 Complete
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Paranta is developing an inhaled form of PB01 for the treatment of cystic fibrosis lung disease. Inhaled PB01 offers a potential step change in the treatment landscape for CF patients, by targeting the underlying lung inflammation and fibrosis which occurs in CF.
Positive safety and tolerability with inhaled PB01 has been demonstrated in three Phase 1 clinical studies in healthy volunteers. The studies were undertaken in Australia and in the UK. Paranta is now focused on advancing the clinical development of inhaled PB01 in CF with input from local and global CF experts.
Preclinical
Read moreAn injectable form of PB01 is being developed as a treatment for diabetic nephropathy, a major comorbidity of diabetes. Preliminary preclinical studies have demonstrated PB01’s ability to reduce kidney damage and fibrosis in a mouse model of diabetic nephropathy. This work forms part of a collaborative research project with McMaster University, Canada. This research collaboration has recently been expanded to include other forms of chronic kidney disease.
Discovery
Read moreParanta is investigating the effect of intravenous PB01 on the body’s immune system as a potential therapy for treating cancer. This research is being undertaken in collaboration with a leading Australian medical research institute. Encouraging preliminary results in animal studies have been produced.
Paranta Biosciences has progressed its recombinant human form of follistatin PB01
Paranta Biosciences is focused on the development and commercialization of transformative medicines, based on the follistatin-activin pathway, to treat inflammatory, fibrotic and metabolic diseases. We welcome interest from parties looking to establish new alliances or collaboration opportunities that complement our research efforts and align with Paranta's corporate strategy.
We are open to collaborations that enable our partners to develop and commercialize Paranta's technologies worldwide, including out-licensing and R&D partnerships, and collaborations that maximize the potential of our pipeline, and our ability to deliver treatments to patients around the globe.
If you would like to discuss partnering with Paranta, please contact Amanda Reese: amanda.reese@parantabio.com